Marble Burying Test Rats

Probe burying test in rats.

Marble burying test rats.

It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. We tested the possibility that a genetic component underlies marble burying in mice and if there is a genetic correlation with other anxiety like traits. This behavior belongs is probably a type of defensive burying typical of rodents 13. Zimeldine 10 0 mg kg reduced marble burying without affecting locomotor activity.

Gene editing eases the frantic burying of marbles bottom right in a mouse model of fragile x syndrome bottom left. Behav brain res 2007. Table 3 marble burying behavior in a two compartment box no. An increasing number of investigators utilize the marble burying assay despite the paucity of information available regarding what underlies the behavior.

The marble burying test is a useful model of both obsessive compulsive like ocd behavior and or anxiety like behavior. When put in a cage with marbles mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging while mice with a high degree of anxiety tend to engage in a high degree of digging in. 3 interactive class activities to energize your online classroom. It has also been proposed that the test may have predictive validity.

In the marble burying test in rats it. The marble burying test is a useful model of neophobia 12 anxiety and obsessive compulsive behaviour. In the marble burying test wky females but not males exhibited a trend towards increased burying indicative of anxiety like neophobic behaviour. The marble burying test takes advantage of the proclivity of mice to dig in natural settings e g.

Of duration of marbles buried test s mean sem time of nonmarble side s mean sem time nonmarble side 300 600 1800 4 2 2 0 7 3 0 9 8 4 0 4 143 4 292 30 916 45 47 ns 49 ns 51 ns data from 10 female. Since findings reported in the literature indicate that marble burying behavior. Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11. Burrows escape tunnels and in standard cage bedding and the nestlet shred test capitalizes on the fact that mice are nesting animals by nature that build nests for protection of themselves and their offspring against environmental conditions e.

In comparison wky males but not females exhibited enhanced novelty induced hypophagia indicative of increased anxiety like behaviour compared to sd rats. While widely used there is significant controversy over the interpretation of its results.